Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus.

Fan, Wei; Liang, Dong; Tang, Yuanjia; Qu, Bo; Cui, Huijuan; Luo, Xiaobing; Huang, Xinfang; Chen, Shunle; Higgs, Brandon W; Jallal, Bahija; Yao, Yihong; Harley, John B; Shen, Nan

Fan, Wei; Liang, Dong; Tang, Yuanjia; Qu, Bo; Cui, Huijuan; Luo, Xiaobing; Huang, Xinfang; Chen, Shunle; Higgs, Brandon W; Jallal, Bahija; Yao, Yihong; Harley, John B; Shen, Nan.

Affiliation

Fan W; Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences, Shanghai JiaoTong University School of Medicine, Chinese Academy of Sciences, China.

Arthritis Rheum ; 64(11): 3715-25, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22736314

Subject(s)

Interleukin-2/genetics; Lupus Erythematosus, Systemic/genetics; Lupus Erythematosus, Systemic/immunology; MicroRNAs/immunology; T-Lymphocytes/immunology; Gene Expression Regulation/genetics; Gene Expression Regulation/immunology; Humans; Interleukin-2/deficiency; Interleukin-2/immunology; Jurkat Cells; Lupus Erythematosus, Systemic/metabolism; NFATC Transcription Factors/genetics; NFATC Transcription Factors/immunology; Primary Cell Culture; Promoter Regions, Genetic/genetics; Promoter Regions, Genetic/immunology; RNA, Small Interfering/genetics; Signal Transduction/genetics; Signal Transduction/immunology; T-Lymphocytes/metabolism; rhoA GTP-Binding Protein/genetics; rhoA GTP-Binding Protein/immunology

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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes / Interleukin-2 / MicroRNAs / Lupus Erythematosus, Systemic Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Year: 2012 Type: Article

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