Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid in colon cancer.

Parolin, Carola; Calonghi, Natalia; Presta, Enrica; Boga, Carla; Caruana, Paolo; Naldi, Marina; Andrisano, Vincenza; Masotti, Lanfranco; Sartor, Giorgio

Parolin, Carola; Calonghi, Natalia; Presta, Enrica; Boga, Carla; Caruana, Paolo; Naldi, Marina; Andrisano, Vincenza; Masotti, Lanfranco; Sartor, Giorgio.

Affiliation

Parolin C; Department of Biochemistry "G. Moruzzi", Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy.

Biochim Biophys Acta ; 1821(10): 1334-40, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22814230

Subject(s)

Histone Deacetylase 1/antagonists & inhibitors; Histone Deacetylase Inhibitors/pharmacology; Stearic Acids/pharmacology; Cell Proliferation/drug effects; Cyclin D1/analysis; Cyclin-Dependent Kinase Inhibitor p21/analysis; HT29 Cells; Histone Deacetylase Inhibitors/chemistry; Humans; Protein Conformation; Stearic Acids/chemistry; Stereoisomerism

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Full text: 1 Database: MEDLINE Main subject: Stearic Acids / Histone Deacetylase 1 / Histone Deacetylase Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Year: 2012 Type: Article

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