Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells.

Nanjappa, Som Gowda; Heninger, Erika; Wüthrich, Marcel; Gasper, David Joseph; Klein, Bruce S

Nanjappa, Som Gowda; Heninger, Erika; Wüthrich, Marcel; Gasper, David Joseph; Klein, Bruce S.

Affiliation

Nanjappa SG; The Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, United States of America.

PLoS Pathog ; 8(7): e1002771, 2012.

Article in En | MEDLINE | ID: mdl-22829762

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Fungal Vaccines/immunology; Lung Diseases, Fungal/immunology; Pneumonia/immunology; Th17 Cells/immunology; Animals; Blastomyces/immunology; Blastomyces/pathogenicity; Blastomycosis/immunology; CD8-Positive T-Lymphocytes/immunology; Cell Differentiation/immunology; Hepatocyte Nuclear Factor 1-alpha; Histoplasma/immunology; Histoplasma/pathogenicity; Histoplasmosis/immunology; Immunocompromised Host; Immunologic Deficiency Syndromes/immunology; Immunologic Memory/immunology; Interleukin-12/biosynthesis; Interleukin-17/biosynthesis; Interleukin-17/immunology; Interleukin-6/biosynthesis; Interleukin-6/immunology; Lectins, C-Type/metabolism; Lung/immunology; Lung/microbiology; Lung Diseases, Fungal/microbiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils/immunology; Pneumonia/microbiology; Receptors, CCR6/biosynthesis; Receptors, CCR6/metabolism; Receptors, CXCR3/biosynthesis; Receptors, Immunologic/biosynthesis; Signal Transduction; T Cell Transcription Factor 1/biosynthesis

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Full text: 1 Database: MEDLINE Main subject: Pneumonia / Fungal Vaccines / CD4-Positive T-Lymphocytes / Th17 Cells / Lung Diseases, Fungal Type of study: Prognostic_studies Language: En Year: 2012 Type: Article

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