Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists.

Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki

Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki.

Affiliation

Negoro K; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. kenji.negoro@astellas.com

Bioorg Med Chem ; 20(17): 5235-46, 2012 Sep 01.

Article in En | MEDLINE | ID: mdl-22836190

Subject(s)

Diabetes Mellitus, Experimental/drug therapy; Drug Discovery; Hypoglycemic Agents/pharmacology; Pyrimidines/pharmacology; Receptors, G-Protein-Coupled/agonists; Administration, Oral; Animals; Cytochrome P-450 CYP1A2/metabolism; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Glucose Tolerance Test; HEK293 Cells; Haplorhini; Humans; Hypoglycemic Agents/administration & dosage; Hypoglycemic Agents/chemistry; Male; Mice; Mice, Inbred ICR; Molecular Structure; Pyrimidines/administration & dosage; Pyrimidines/chemistry; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Receptors, G-Protein-Coupled / Diabetes Mellitus, Experimental / Drug Discovery / Hypoglycemic Agents Limits: Animals / Humans / Male Language: En Year: 2012 Type: Article

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