A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.

Fan, Xuejun; Brezski, Randall J; Fa, Ming; Deng, Hui; Oberholtzer, Allison; Gonzalez, Anneliese; Dubinsky, William P; Strohl, William R; Jordan, Robert E; Zhang, Ningyan; An, Zhiqiang

Fan, Xuejun; Brezski, Randall J; Fa, Ming; Deng, Hui; Oberholtzer, Allison; Gonzalez, Anneliese; Dubinsky, William P; Strohl, William R; Jordan, Robert E; Zhang, Ningyan; An, Zhiqiang.

Breast Cancer Res ; 14(4): R116, 2012 Aug 08.

Article in En | MEDLINE | ID: mdl-22873525

Subject(s)

Antibodies, Monoclonal, Humanized/metabolism; Amino Acid Sequence; Animals; Antibodies, Monoclonal, Humanized/chemistry; Antibodies, Monoclonal, Humanized/immunology; Antibodies, Monoclonal, Humanized/pharmacology; Antibody-Dependent Cell Cytotoxicity/immunology; Cell Line; Disease Models, Animal; Female; Humans; Matrix Metalloproteinases/metabolism; Mice; Molecular Sequence Data; Neoplasms/drug therapy; Neoplasms/immunology; Neoplasms/pathology; Protein Binding; Proteolysis; Receptor, ErbB-2/antagonists & inhibitors; Receptor, ErbB-2/metabolism; Receptors, IgG/metabolism; Trastuzumab; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Antibodies, Monoclonal, Humanized Limits: Animals / Female / Humans Language: En Year: 2012 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Antibodies, Monoclonal, Humanized Limits: Animals / Female / Humans Language: En Year: 2012 Type: Article