The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis.

Tyler, Andrea D; Milgrom, Raquel; Stempak, Joanne M; Xu, Wei; Brumell, John Hunter; Muise, Aleixo M; Sehgal, Rishabh; Cohen, Zane; Koltun, Walter; Shen, Bo; Silverberg, Mark S

Tyler, Andrea D; Milgrom, Raquel; Stempak, Joanne M; Xu, Wei; Brumell, John Hunter; Muise, Aleixo M; Sehgal, Rishabh; Cohen, Zane; Koltun, Walter; Shen, Bo; Silverberg, Mark S.

Affiliation

Tyler AD; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

Gut ; 62(10): 1433-9, 2013 Oct.

Article in En | MEDLINE | ID: mdl-22879519

Subject(s)

Colitis, Ulcerative/genetics; Colitis, Ulcerative/surgery; Colonic Pouches/adverse effects; Nod2 Signaling Adaptor Protein/genetics; Polymorphism, Single Nucleotide; Acute Disease; Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Crohn Disease/etiology; Crohn Disease/genetics; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Pouchitis/etiology; Pouchitis/genetics; Prognosis; Retrospective Studies; Risk Factors; Treatment Outcome

Key words

Ileal pouch-anal anastomosis; NOD2; inflammatory bowel disease genetics; restorative proctocolectomy; ulcerative colitis

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Full text: 1 Database: MEDLINE Main subject: Colitis, Ulcerative / Polymorphism, Single Nucleotide / Colonic Pouches / Nod2 Signaling Adaptor Protein Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Language: En Year: 2013 Type: Article

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