Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation.

Xu, Yi-Fan; Zhao, Xin; Glass, David S; Absalan, Farnaz; Perlman, David H; Broach, James R; Rabinowitz, Joshua D.

Affiliation

Xu YF; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

Mol Cell ; 48(1): 52-62, 2012 Oct 12.

Article in En | MEDLINE | ID: mdl-22902555

Subject(s)

Pyruvate Kinase/metabolism; Saccharomyces cerevisiae/enzymology; Allosteric Regulation; Fructosediphosphates/metabolism; Genes, Fungal; Glucose/metabolism; Isoenzymes/genetics; Isoenzymes/metabolism; Metabolome; Phosphoenolpyruvate/metabolism; Phosphorylation; Point Mutation; Pyruvate Kinase/genetics; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Transcriptome