Metallothionein blocks oxidative DNA damage in vitro.

Qu, Wei; Pi, Jingbo; Waalkes, Michael P

Qu, Wei; Pi, Jingbo; Waalkes, Michael P.

Affiliation

Qu W; Inorganic Toxicology Group, National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

Arch Toxicol ; 87(2): 311-21, 2013 Feb.

Article in En | MEDLINE | ID: mdl-22914987

Subject(s)

DNA Damage; Embryonic Stem Cells/drug effects; Metallothionein/metabolism; Oxidants/toxicity; Oxidative Stress/drug effects; Animals; Cadmium Chloride/toxicity; Cell Line; Cell Survival/drug effects; Embryonic Stem Cells/metabolism; Gene Expression/drug effects; Gene Expression Regulation/drug effects; Gene Knockdown Techniques; Glutathione Transferase/genetics; Heme Oxygenase-1/genetics; Heme Oxygenase-1/metabolism; Hydrogen Peroxide/toxicity; Isoenzymes/genetics; Membrane Proteins/genetics; Membrane Proteins/metabolism; Metallothionein/deficiency; Metallothionein/genetics; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins/genetics; Multidrug Resistance-Associated Proteins/metabolism; Transfection

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: DNA Damage / Oxidants / Oxidative Stress / Embryonic Stem Cells / Metallothionein Limits: Animals Language: En Year: 2013 Type: Article

Fulltext

XML

PubMed Links

Search on Google