Cholesterol depletion by methyl-ß-cyclodextrin enhances cell proliferation and increases the number of desmin-positive cells in myoblast cultures.

Portilho, Débora M; Soares, Carolina P; Morrot, Alexandre; Thiago, Leandro S; Butler-Browne, Gillian; Savino, Wilson; Costa, Manoel L; Mermelstein, Cláudia

Portilho, Débora M; Soares, Carolina P; Morrot, Alexandre; Thiago, Leandro S; Butler-Browne, Gillian; Savino, Wilson; Costa, Manoel L; Mermelstein, Cláudia.

Affiliation

Portilho DM; Laboratório de Diferenciação Muscular e Citoesqueleto, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil.

Eur J Pharmacol ; 694(1-3): 1-12, 2012 Nov 05.

Article in En | MEDLINE | ID: mdl-22921450

Subject(s)

Cholesterol/deficiency; Desmin/metabolism; Myoblasts/cytology; Myoblasts/metabolism; beta-Cyclodextrins/pharmacology; Animals; Bromodeoxyuridine/metabolism; Cell Count; Cell Proliferation/drug effects; Cell Survival/drug effects; Chick Embryo; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Gene Expression Regulation/drug effects; Muscle Development/drug effects; MyoD Protein/metabolism; Myoblasts/drug effects; Organ Specificity; Signal Transduction/drug effects; Tumor Suppressor Protein p53/metabolism; Wnt Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Cholesterol / Myoblasts / Beta-Cyclodextrins / Desmin Limits: Animals Language: En Year: 2012 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Cholesterol / Myoblasts / Beta-Cyclodextrins / Desmin Limits: Animals Language: En Year: 2012 Type: Article