Phenethyl nicotinamides, a novel class of Na(V)1.7 channel blockers: structure and activity relationship.

Kers, Inger; Macsari, Istvan; Csjernyik, Gabor; Nylöf, Martin; Skogholm, Karin; Sandberg, Lars; Minidis, Alexander; Bueters, Tjerk; Malmborg, Jonas; Eriksson, Anders B; Lund, Per-Eric; Venyike, Elisabet; Luo, Lei; Nyström, Jan-Erik; Besidski, Yevgeni

Kers, Inger; Macsari, Istvan; Csjernyik, Gabor; Nylöf, Martin; Skogholm, Karin; Sandberg, Lars; Minidis, Alexander; Bueters, Tjerk; Malmborg, Jonas; Eriksson, Anders B; Lund, Per-Eric; Venyike, Elisabet; Luo, Lei; Nyström, Jan-Erik; Besidski, Yevgeni.

Affiliation

Kers I; Medicinal Chemistry, CNSP iMed Science, AstraZeneca R&D, Innovative Medicines, SE-15185 Södertälje, Sweden. inger.kers@astrazeneca.com

Bioorg Med Chem Lett ; 22(19): 6108-15, 2012 Oct 01.

Article in En | MEDLINE | ID: mdl-22939696

Subject(s)

NAV1.7 Voltage-Gated Sodium Channel/metabolism; Niacinamide/analogs & derivatives; Niacinamide/pharmacology; Sodium Channel Blockers/pharmacology; Animals; Dose-Response Relationship, Drug; Humans; Microsomes, Liver/chemistry; Microsomes, Liver/metabolism; Molecular Structure; Niacinamide/chemical synthesis; Niacinamide/chemistry; Rats; Sodium Channel Blockers/chemical synthesis; Sodium Channel Blockers/chemistry; Solubility; Stereoisomerism; Structure-Activity Relationship

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Niacinamide / Sodium Channel Blockers / NAV1.7 Voltage-Gated Sodium Channel Limits: Animals / Humans Language: En Year: 2012 Type: Article

Fulltext

XML

PubMed Links

Search on Google