Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.

Carmody, Leigh C; Germain, Andrew R; VerPlank, Lynn; Nag, Partha P; Muñoz, Benito; Perez, Jose R; Palmer, Michelle A J

Carmody, Leigh C; Germain, Andrew R; VerPlank, Lynn; Nag, Partha P; Muñoz, Benito; Perez, Jose R; Palmer, Michelle A J.

Affiliation

Carmody LC; Chemical Biology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. lcarmody@broadinstitute.org

J Biomol Screen ; 17(9): 1204-10, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22941295

Subject(s)

Breast Neoplasms/metabolism; High-Throughput Screening Assays/methods; Hydrazones/pharmacology; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/metabolism; Pyrroles/pharmacology; Small Molecule Libraries/pharmacology; Cell Line, Tumor; Cell Proliferation/drug effects; Epithelial-Mesenchymal Transition/drug effects; Female; Gene Expression Profiling; Humans; Hydrazones/chemistry; Inhibitory Concentration 50; NF-kappa B/metabolism; Neoplastic Stem Cells/cytology

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Database: MEDLINE Main subject: Pyrroles / Neoplastic Stem Cells / Breast Neoplasms / Small Molecule Libraries / High-Throughput Screening Assays / Hydrazones Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Female / Humans Language: En Year: 2012 Type: Article

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