In vitro antifungal activity of isavuconazole against Madurella mycetomatis.
Antimicrob Agents Chemother
; 56(11): 6054-6, 2012 Nov.
Article
in En
| MEDLINE
| ID: mdl-22964246
ABSTRACT
Currently, therapy of black-grain mycetoma caused by Madurella mycetomatis consists of extensive debridement of the infected tissue combined with prolonged antifungal therapy with ketoconazole or itraconazole. In the present study, the in vitro activity of the new triazole isavuconazole toward M. mycetomatis was evaluated. Isavuconazole appeared to have high activity against M. mycetomatis, with MICs ranging from ≤0.016 to 0.125 µg/ml. Due to its favorable pharmacokinetics, isavuconazole could be a promising antifungal agent in the treatment of mycetoma.
Full text:
1
Database:
MEDLINE
Main subject:
Pyridines
/
Triazoles
/
Itraconazole
/
Madurella
/
Ketoconazole
/
Antifungal Agents
/
Nitriles
Limits:
Humans
Language:
En
Year:
2012
Type:
Article