Mechanism of inverse agonist action of sarpogrelate at the constitutively active mutant of human 5-HT2A receptor revealed by molecular modeling.

Hossain, Murad; Muntasir, Habib Abul; Ishiguro, Masaji; Bhuiyan, Mohiuddin Ahmed; Rashid, Mamunur; Sugihara, Takumichi; Nagatomo, Takafumi

Hossain, Murad; Muntasir, Habib Abul; Ishiguro, Masaji; Bhuiyan, Mohiuddin Ahmed; Rashid, Mamunur; Sugihara, Takumichi; Nagatomo, Takafumi.

Affiliation

Hossain M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.

Biol Pharm Bull ; 35(9): 1553-9, 2012.

Article in En | MEDLINE | ID: mdl-22975508

Subject(s)

Mutation; Receptor, Serotonin, 5-HT2A/metabolism; Serotonin 5-HT2 Receptor Antagonists/pharmacology; Succinates/pharmacology; HEK293 Cells; Humans; Models, Molecular; Protein Structure, Secondary; Receptor, Serotonin, 5-HT2A/chemistry; Receptor, Serotonin, 5-HT2A/genetics

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Database: MEDLINE Main subject: Succinates / Receptor, Serotonin, 5-HT2A / Serotonin 5-HT2 Receptor Antagonists / Mutation Limits: Humans Language: En Year: 2012 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Succinates / Receptor, Serotonin, 5-HT2A / Serotonin 5-HT2 Receptor Antagonists / Mutation Limits: Humans Language: En Year: 2012 Type: Article