The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide.

Cassone, Marco; Gagne, Alyssa L; Spruce, Lynn A; Seeholzer, Steven H; Sebert, Michael E

Cassone, Marco; Gagne, Alyssa L; Spruce, Lynn A; Seeholzer, Steven H; Sebert, Michael E.

Affiliation

Cassone M; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

J Biol Chem ; 287(46): 38449-59, 2012 Nov 09.

Article in En | MEDLINE | ID: mdl-23012372

Subject(s)

Peptide Hydrolases/chemistry; Serine Proteases/physiology; Streptococcus pneumoniae/enzymology; Bacterial Physiological Phenomena; Binding Sites; Catalytic Domain; Fluorescence Resonance Energy Transfer; Gene Deletion; Kinetics; Mass Spectrometry/methods; Mutation; Peptides/chemistry; Polymerase Chain Reaction/methods; Protein Denaturation; Proteolysis; Quorum Sensing; Serine Proteases/chemistry; Signal Transduction

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Full text: 1 Database: MEDLINE Main subject: Peptide Hydrolases / Streptococcus pneumoniae / Serine Proteases Type of study: Prognostic_studies Language: En Year: 2012 Type: Article

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