Global identification of peptidase specificity by multiplex substrate profiling.

O'Donoghue, Anthony J; Eroy-Reveles, A Alegra; Knudsen, Giselle M; Ingram, Jessica; Zhou, Min; Statnekov, Jacob B; Greninger, Alexander L; Hostetter, Daniel R; Qu, Gang; Maltby, David A; Anderson, Marc O; Derisi, Joseph L; McKerrow, James H; Burlingame, Alma L; Craik, Charles S

O'Donoghue, Anthony J; Eroy-Reveles, A Alegra; Knudsen, Giselle M; Ingram, Jessica; Zhou, Min; Statnekov, Jacob B; Greninger, Alexander L; Hostetter, Daniel R; Qu, Gang; Maltby, David A; Anderson, Marc O; Derisi, Joseph L; McKerrow, James H; Burlingame, Alma L; Craik, Charles S.

Affiliation

O'Donoghue AJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, USA.

Nat Methods ; 9(11): 1095-100, 2012 Nov.

Article in En | MEDLINE | ID: mdl-23023596

Subject(s)

Peptide Hydrolases/metabolism; Substrate Specificity; 3C Viral Proteases; Animals; Carboxypeptidases/metabolism; Carcinoma, Pancreatic Ductal/enzymology; Cathepsin E/metabolism; Cell Line, Tumor; Chromatography, Liquid; Cysteine Endopeptidases/metabolism; Exopeptidases/metabolism; Granzymes/metabolism; Humans; Mice; Pancreatic Elastase/metabolism; Peptide Library; Peptides/metabolism; Schistosoma mansoni; Tandem Mass Spectrometry; Viral Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Peptide Hydrolases / Substrate Specificity Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Year: 2012 Type: Article

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