Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.

Chiu, Gabriel S; Chatterjee, Diptaman; Darmody, Patrick T; Walsh, John P; Meling, Daryl D; Johnson, Rodney W; Freund, Gregory G

Chiu, Gabriel S; Chatterjee, Diptaman; Darmody, Patrick T; Walsh, John P; Meling, Daryl D; Johnson, Rodney W; Freund, Gregory G.

Affiliation

Chiu GS; Division of Nutritional Sciences, Program in Integrative Immunology and Behavior, University of Illinois, Urbana Illinois 61801, USA.

J Neurosci ; 32(40): 13945-55, 2012 Oct 03.

Article in En | MEDLINE | ID: mdl-23035103

Subject(s)

Adenosine/physiology; Amnesia, Anterograde/enzymology; Amygdala/physiology; Caspase 1/physiology; Hypoxia, Brain/complications; Adenosine/pharmacology; Amino Acid Chloromethyl Ketones/pharmacology; Amnesia, Anterograde/etiology; Amnesia, Anterograde/physiopathology; Amygdala/drug effects; Amygdala/enzymology; Animals; Caffeine/pharmacology; Caspase 1/drug effects; Caspase Inhibitors/pharmacology; Conditioning, Classical/drug effects; Conditioning, Classical/physiology; Cues; Enzyme Activation; Fear/drug effects; Fear/physiology; Hypoxia, Brain/physiopathology; Interleukin 1 Receptor Antagonist Protein/pharmacology; MAP Kinase Signaling System; Male; Maze Learning/drug effects; Maze Learning/physiology; Mental Recall; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxygen/metabolism; Oxygen/pharmacology; Receptors, Interleukin-1 Type I/deficiency; Receptors, Purinergic P1/physiology; Recognition, Psychology/drug effects; Recognition, Psychology/physiology; Theobromine/analogs & derivatives; Theobromine/pharmacology; Xanthines/pharmacology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Adenosine / Hypoxia, Brain / Caspase 1 / Amnesia, Anterograde / Amygdala Type of study: Etiology_studies Language: En Year: 2012 Type: Article

Fulltext

XML

PubMed Links

Search on Google