Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport.

Mitchell, David J; Blasier, Kiev R; Jeffery, Erin D; Ross, Mitchell W; Pullikuth, Ashok K; Suo, Dong; Park, Juyeon; Smiley, W Russell; Lo, Kevin W-H; Shabanowitz, Jeffrey; Deppmann, Christopher D; Trinidad, Jonathan C; Hunt, Donald F; Catling, Andrew D; Pfister, K Kevin

Mitchell, David J; Blasier, Kiev R; Jeffery, Erin D; Ross, Mitchell W; Pullikuth, Ashok K; Suo, Dong; Park, Juyeon; Smiley, W Russell; Lo, Kevin W-H; Shabanowitz, Jeffrey; Deppmann, Christopher D; Trinidad, Jonathan C; Hunt, Donald F; Catling, Andrew D; Pfister, K Kevin.

Affiliation

Mitchell DJ; Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA.

J Neurosci ; 32(44): 15495-510, 2012 Oct 31.

Article in En | MEDLINE | ID: mdl-23115187

Subject(s)

Axonal Transport/physiology; Cytoplasm/physiology; Dyneins/physiology; Endosomes/physiology; MAP Kinase Signaling System/physiology; Receptor, trkA/physiology; Animals; Blotting, Western; Cell Membrane/metabolism; Cell Membrane/physiology; Cell Survival/physiology; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; MAP Kinase Signaling System/genetics; Nerve Growth Factor/physiology; Nerve Growth Factors/pharmacology; Neurons/physiology; Organelles/physiology; PC12 Cells; Phosphorylation; Plasmids/genetics; RNA, Small Interfering/genetics; Rats; Signal Transduction/physiology; Transfection

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Full text: 1 Database: MEDLINE Main subject: Endosomes / Axonal Transport / Dyneins / Receptor, trkA / MAP Kinase Signaling System / Cytoplasm Type of study: Prognostic_studies Limits: Animals Language: En Year: 2012 Type: Article

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