Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis.

Martin, Ina V; Borkham-Kamphorst, Erawan; Zok, Stephanie; van Roeyen, Claudia R C; Eriksson, Ulf; Boor, Peter; Hittatiya, Kanishka; Fischer, Hans-Peter; Wasmuth, Hermann E; Weiskirchen, Ralf; Eitner, Frank; Floege, Jürgen; Ostendorf, Tammo

Martin, Ina V; Borkham-Kamphorst, Erawan; Zok, Stephanie; van Roeyen, Claudia R C; Eriksson, Ulf; Boor, Peter; Hittatiya, Kanishka; Fischer, Hans-Peter; Wasmuth, Hermann E; Weiskirchen, Ralf; Eitner, Frank; Floege, Jürgen; Ostendorf, Tammo.

Affiliation

Martin IV; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.

Am J Pathol ; 182(1): 107-17, 2013 Jan.

Article in En | MEDLINE | ID: mdl-23141925

Subject(s)

Kidney/pathology; Liver Cirrhosis/metabolism; Lymphokines/physiology; Platelet-Derived Growth Factor/physiology; Receptors, Platelet-Derived Growth Factor/physiology; Animals; Cells, Cultured; Disease Models, Animal; Fibrosis; Liver Cirrhosis/etiology; Liver Cirrhosis/prevention & control; Lymphokines/antagonists & inhibitors; Lymphokines/deficiency; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts/metabolism; Platelet-Derived Growth Factor/antagonists & inhibitors; Platelet-Derived Growth Factor/deficiency; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor/metabolism; Signal Transduction/physiology; Up-Regulation/physiology; Ureteral Obstruction/complications

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Full text: 1 Database: MEDLINE Main subject: Platelet-Derived Growth Factor / Lymphokines / Receptors, Platelet-Derived Growth Factor / Kidney / Liver Cirrhosis Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Year: 2013 Type: Article

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