TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.

Gonzalvez, Francois; Lawrence, David; Yang, Becky; Yee, Sharon; Pitti, Robert; Marsters, Scot; Pham, Victoria C; Stephan, Jean-Philippe; Lill, Jennie; Ashkenazi, Avi

Gonzalvez, Francois; Lawrence, David; Yang, Becky; Yee, Sharon; Pitti, Robert; Marsters, Scot; Pham, Victoria C; Stephan, Jean-Philippe; Lill, Jennie; Ashkenazi, Avi.

Affiliation

Gonzalvez F; Department of Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA.

Mol Cell ; 48(6): 888-99, 2012 Dec 28.

Article in En | MEDLINE | ID: mdl-23142077

Subject(s)

Apoptosis; Caspase 8/metabolism; Protein Processing, Post-Translational; Proteolysis; TNF Receptor-Associated Factor 2/physiology; Amino Acid Sequence; Animals; Catalytic Domain; Cell Survival; Cullin Proteins/metabolism; Death Domain Receptor Signaling Adaptor Proteins/metabolism; Enzyme Activation; HCT116 Cells; Humans; Leupeptins/pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Peptide Mapping; Proteasome Endopeptidase Complex/metabolism; Proteasome Inhibitors/pharmacology; TNF Receptor-Associated Factor 2/genetics; TNF Receptor-Associated Factor 2/metabolism; Ubiquitination

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Full text: 1 Database: MEDLINE Main subject: Protein Processing, Post-Translational / Apoptosis / TNF Receptor-Associated Factor 2 / Caspase 8 / Proteolysis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2012 Type: Article

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