Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector.

Figueiredo, Ana C; de Sanctis, Daniele; Gutiérrez-Gallego, Ricardo; Cereija, Tatiana B; Macedo-Ribeiro, Sandra; Fuentes-Prior, Pablo; Pereira, Pedro José Barbosa

Figueiredo, Ana C; de Sanctis, Daniele; Gutiérrez-Gallego, Ricardo; Cereija, Tatiana B; Macedo-Ribeiro, Sandra; Fuentes-Prior, Pablo; Pereira, Pedro José Barbosa.

Affiliation

Figueiredo AC; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4150-180 Porto, Portugal.

Proc Natl Acad Sci U S A ; 109(52): E3649-58, 2012 Dec 26.

Article in En | MEDLINE | ID: mdl-23223529

Subject(s)

Anticoagulants/pharmacology; Antithrombins/pharmacology; Insect Proteins/pharmacology; Insect Vectors/chemistry; Malaria/parasitology; Salivary Proteins and Peptides/pharmacology; Thrombin/antagonists & inhibitors; Amino Acid Sequence; Animals; Anopheles/chemistry; Anticoagulants/chemistry; Antithrombins/chemistry; Arginine/metabolism; Blood Coagulation/drug effects; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Humans; Immobilized Proteins/metabolism; Insect Proteins/chemistry; Kinetics; Models, Molecular; Molecular Sequence Data; Protein Binding/drug effects; Protein Stability/drug effects; Salivary Proteins and Peptides/chemistry; Sequence Alignment; Structure-Activity Relationship; Substrate Specificity/drug effects; Surface Plasmon Resonance; Thrombin/metabolism; Thrombin Time

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Full text: 1 Database: MEDLINE Main subject: Salivary Proteins and Peptides / Thrombin / Antithrombins / Insect Proteins / Insect Vectors / Malaria / Anticoagulants Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2012 Type: Article

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