Accessory gene regulator (agr) dysfunction in Staphylococcus aureus bloodstream isolates from South Korean patients.
Antimicrob Agents Chemother
; 57(3): 1509-12, 2013 Mar.
Article
in En
| MEDLINE
| ID: mdl-23254438
ABSTRACT
We describe the genetic and microbiological characteristics of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates with agr dysfunction from a tertiary-care hospital in Korea. Of these, ST5-SCCmec type II-agr group II MRSA isolates, which are known to be prevalent in hospital-acquired infections in Korea, were the most abundant, because of the clonal spread of a specific agr-defective lineage. This finding suggests that the loss of agr function may confer a potential advantage in a hospital setting. Clonal spread of a specific defective-agr strain was not observed among community-associated MRSA or methicillin-susceptible S. aureus clones, regardless of community or hospital acquisition of infection. agr-defective clones, including ST5 and ST239 MRSA, were enriched for heteroresistant vancomycin-intermediate S. aureus.
Full text:
1
Database:
MEDLINE
Main subject:
Staphylococcal Infections
/
Bacterial Proteins
/
Trans-Activators
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Cross Infection
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Methicillin-Resistant Staphylococcus aureus
/
Mutation
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Year:
2013
Type:
Article