Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators.

Gehrke, Sebastian S; Pinto, Erika G; Steverding, Dietmar; Pleban, Karin; Tempone, Andre G; Hider, Robert C; Wagner, Gerd K

Gehrke, Sebastian S; Pinto, Erika G; Steverding, Dietmar; Pleban, Karin; Tempone, Andre G; Hider, Robert C; Wagner, Gerd K.

Affiliation

Gehrke SS; Institute of Pharmaceutical Science, School of Biomedical Sciences, King's College London, SE19NH, UK.

Bioorg Med Chem ; 21(3): 805-13, 2013 Feb 01.

Article in En | MEDLINE | ID: mdl-23266185

Subject(s)

Aminoquinolines/chemistry; Antiprotozoal Agents/pharmacology; Iron Chelating Agents/pharmacology; Pyridones/pharmacology; Antiprotozoal Agents/chemical synthesis; Antiprotozoal Agents/chemistry; Deferiprone; Dose-Response Relationship, Drug; Iron Chelating Agents/chemical synthesis; Iron Chelating Agents/chemistry; Leishmania infantum/drug effects; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum/drug effects; Pyridones/chemical synthesis; Pyridones/chemistry; Structure-Activity Relationship; Trypanosoma brucei brucei/drug effects; Trypanosoma cruzi/drug effects

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Full text: 1 Database: MEDLINE Main subject: Pyridones / Iron Chelating Agents / Aminoquinolines / Antiprotozoal Agents Language: En Year: 2013 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Pyridones / Iron Chelating Agents / Aminoquinolines / Antiprotozoal Agents Language: En Year: 2013 Type: Article