Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts.

Ebermann, Linda; Ruzsics, Zsolt; Guzmán, Carlos A; van Rooijen, Nico; Casalegno-Garduño, Rosaely; Koszinowski, Ulrich; Cicin-Sain, Luka

Ebermann, Linda; Ruzsics, Zsolt; Guzmán, Carlos A; van Rooijen, Nico; Casalegno-Garduño, Rosaely; Koszinowski, Ulrich; Cicin-Sain, Luka.

Affiliation

Ebermann L; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

PLoS Pathog ; 8(12): e1003062, 2012.

Article in En | MEDLINE | ID: mdl-23271968

Subject(s)

Adaptive Immunity; Common Variable Immunodeficiency/immunology; Herpesviridae Infections/immunology; Macrophages/immunology; Muromegalovirus/immunology; Amino Acid Chloromethyl Ketones/pharmacology; Animals; Cell Line; Common Variable Immunodeficiency/genetics; Common Variable Immunodeficiency/pathology; Common Variable Immunodeficiency/virology; Cysteine Proteinase Inhibitors/pharmacology; Fibroblasts/immunology; Fibroblasts/pathology; Fibroblasts/virology; Herpesviridae Infections/genetics; Herpesviridae Infections/pathology; Humans; Interferon-gamma/genetics; Interferon-gamma/immunology; Macrophages/pathology; Macrophages/virology; Mice; Mice, Knockout; Muromegalovirus/genetics; Viral Proteins/genetics; Viral Proteins/immunology

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Full text: 1 Database: MEDLINE Main subject: Common Variable Immunodeficiency / Muromegalovirus / Herpesviridae Infections / Adaptive Immunity / Macrophages Limits: Animals / Humans Language: En Year: 2012 Type: Article

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