The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P1) and hypertension (S1P3) in rat.

Fryer, Ryan M; Muthukumarana, Akalushi; Harrison, Paul C; Nodop Mazurek, Suzanne; Chen, Rong Rhonda; Harrington, Kyle E; Dinallo, Roger M; Horan, Joshua C; Patnaude, Lori; Modis, Louise K; Reinhart, Glenn A

Fryer, Ryan M; Muthukumarana, Akalushi; Harrison, Paul C; Nodop Mazurek, Suzanne; Chen, Rong Rhonda; Harrington, Kyle E; Dinallo, Roger M; Horan, Joshua C; Patnaude, Lori; Modis, Louise K; Reinhart, Glenn A.

Affiliation

Fryer RM; Department of Cardiometabolic Disease Research, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America. ryan.fryer@boehringer-ingelheim.com

PLoS One ; 7(12): e52985, 2012.

Article in En | MEDLINE | ID: mdl-23285242

Subject(s)

Azetidines/adverse effects; Benzyl Compounds/adverse effects; Bradycardia/chemically induced; Hypertension/chemically induced; Propylene Glycols/adverse effects; Receptors, Lysosphingolipid/agonists; Sphingosine/analogs & derivatives; Animals; Azetidines/pharmacology; Benzyl Compounds/pharmacology; Bradycardia/pathology; Cells, Cultured; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Hypertension/pathology; Immunosuppressive Agents/adverse effects; Immunosuppressive Agents/pharmacology; Male; Propylene Glycols/pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid/classification; Sphingosine/adverse effects; Sphingosine/pharmacology; Substrate Specificity

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Full text: 1 Database: MEDLINE Main subject: Propylene Glycols / Sphingosine / Azetidines / Benzyl Compounds / Bradycardia / Receptors, Lysosphingolipid / Hypertension Limits: Animals / Humans / Male Language: En Year: 2012 Type: Article

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