Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

Hernandez, Vincent; Crépin, Thibaut; Palencia, Andrés; Cusack, Stephen; Akama, Tsutomu; Baker, Stephen J; Bu, Wei; Feng, Lisa; Freund, Yvonne R; Liu, Liang; Meewan, Maliwan; Mohan, Manisha; Mao, Weimin; Rock, Fernando L; Sexton, Holly; Sheoran, Anita; Zhang, Yanchen; Zhang, Yong-Kang; Zhou, Yasheen; Nieman, James A; Anugula, Mahipal Reddy; Keramane, El Mehdi; Savariraj, Kingsley; Reddy, D Shekhar; Sharma, Rashmi; Subedi, Rajendra; Singh, Rajeshwar; O'Leary, Ann; Simon, Nerissa L; De Marsh, Peter L; Mushtaq, Shazad; Warner, Marina; Livermore, David M; Alley, M R K; Plattner, Jacob J

Hernandez, Vincent; Crépin, Thibaut; Palencia, Andrés; Cusack, Stephen; Akama, Tsutomu; Baker, Stephen J; Bu, Wei; Feng, Lisa; Freund, Yvonne R; Liu, Liang; Meewan, Maliwan; Mohan, Manisha; Mao, Weimin; Rock, Fernando L; Sexton, Holly; Sheoran, Anita; Zhang, Yanchen; Zhang, Yong-Kang; Zhou, Yasheen; Nieman, James A; Anugula, Mahipal Reddy; Keramane, El Mehdi; Savariraj, Kingsley; Reddy, D Shekhar; Sharma, Rashmi; Subedi, Rajendra; Singh, Rajeshwar; O'Leary, Ann; Simon, Nerissa L; De Marsh, Peter L; Mushtaq, Shazad; Warner, Marina; Livermore, David M; Alley, M R K; Plattner, Jacob J.

Affiliation

Hernandez V; Anacor Pharmaceuticals Inc., Palo Alto, CA, USA.

Antimicrob Agents Chemother ; 57(3): 1394-403, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23295920

Subject(s)

Amino Acyl-tRNA Synthetases/antagonists & inhibitors; Anti-Bacterial Agents/pharmacology; Boron Compounds/pharmacology; Escherichia coli/drug effects; Gram-Negative Bacterial Infections/drug therapy; Pseudomonas aeruginosa/drug effects; Amino Acyl-tRNA Synthetases/metabolism; Animals; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/pharmacokinetics; Bacterial Proteins/antagonists & inhibitors; Bacterial Proteins/metabolism; Boron Compounds/chemical synthesis; Boron Compounds/pharmacokinetics; Crystallography, X-Ray; Drug Discovery; Drug Resistance, Multiple, Bacterial/drug effects; Escherichia coli/enzymology; Female; Gram-Negative Bacterial Infections/microbiology; Humans; Leucine/metabolism; Mice; Microbial Sensitivity Tests; Molecular Docking Simulation; Pseudomonas aeruginosa/enzymology; Structure-Activity Relationship; Thigh/microbiology; beta-Lactamase Inhibitors; beta-Lactamases/metabolism

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Full text: 1 Database: MEDLINE Main subject: Pseudomonas aeruginosa / Boron Compounds / Gram-Negative Bacterial Infections / Escherichia coli / Amino Acyl-tRNA Synthetases / Anti-Bacterial Agents Limits: Animals / Female / Humans Language: En Year: 2013 Type: Article

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