Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress.

Choi, Soo-Youn; Jang, Hyonchol; Roe, Jae-Seok; Kim, Seong-Tae; Cho, Eun-Jung; Youn, Hong-Duk

Choi, Soo-Youn; Jang, Hyonchol; Roe, Jae-Seok; Kim, Seong-Tae; Cho, Eun-Jung; Youn, Hong-Duk.

Affiliation

Choi SY; Department of Biomedical Sciences, Department of Biochemistry and Molecular Biology, National Creative Research Center for Epigenome Reprogramming Network, Seoul, Republic of Korea.

Nucleic Acids Res ; 41(4): 2180-90, 2013 Feb 01.

Article in En | MEDLINE | ID: mdl-23303793

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; DNA Damage; Transcriptional Activation; Tumor Suppressor Protein p53/metabolism; Ubiquitination; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins/antagonists & inhibitors; Cell Cycle Proteins/metabolism; Checkpoint Kinase 2; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/metabolism; Humans; Mutagens/toxicity; Phosphorylation; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/metabolism; Proteolysis; Stress, Physiological/genetics; Tumor Suppressor Proteins/antagonists & inhibitors; Tumor Suppressor Proteins/metabolism; Ubiquitin/metabolism; Ubiquitin-Protein Ligases/metabolism

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Full text: 1 Database: MEDLINE Main subject: DNA Damage / Transcriptional Activation / Tumor Suppressor Protein p53 / Adaptor Proteins, Signal Transducing / Ubiquitination Limits: Humans Language: En Year: 2013 Type: Article

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