Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.

Kitay, Brandon M; McCormack, Ryan; Wang, Yunfang; Tsoulfas, Pantelis; Zhai, R Grace

Kitay, Brandon M; McCormack, Ryan; Wang, Yunfang; Tsoulfas, Pantelis; Zhai, R Grace.

Affiliation

Kitay BM; Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA.

Hum Mol Genet ; 22(8): 1601-14, 2013 Apr 15.

Article in En | MEDLINE | ID: mdl-23314018

Subject(s)

Axons/metabolism; Mitochondria/metabolism; Motor Neurons/metabolism; Nicotinamide-Nucleotide Adenylyltransferase/metabolism; Wallerian Degeneration/genetics; Animals; Animals, Genetically Modified; Axons/pathology; Axotomy; Drosophila/genetics; Drosophila/metabolism; Drosophila Proteins/genetics; Frontotemporal Dementia/genetics; Frontotemporal Dementia/pathology; Ganglia, Spinal/metabolism; Ganglia, Spinal/physiopathology; Humans; Mice; Mitochondria/pathology; Motor Neurons/pathology; Nerve Tissue Proteins/genetics; Neurodegenerative Diseases/genetics; Neurodegenerative Diseases/pathology; Nicotinamide-Nucleotide Adenylyltransferase/genetics; Wallerian Degeneration/metabolism; Wallerian Degeneration/pathology

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Full text: 1 Database: MEDLINE Main subject: Axons / Wallerian Degeneration / Mitochondria / Motor Neurons / Nicotinamide-Nucleotide Adenylyltransferase Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2013 Type: Article

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