Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function.

Heideman, Marinus R; Wilting, Roel H; Yanover, Eva; Velds, Arno; de Jong, Johann; Kerkhoven, Ron M; Jacobs, Heinz; Wessels, Lodewyk F; Dannenberg, Jan-Hermen

Heideman, Marinus R; Wilting, Roel H; Yanover, Eva; Velds, Arno; de Jong, Johann; Kerkhoven, Ron M; Jacobs, Heinz; Wessels, Lodewyk F; Dannenberg, Jan-Hermen.

Affiliation

Heideman MR; Division of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands.

Blood ; 121(11): 2038-50, 2013 Mar 14.

Article in En | MEDLINE | ID: mdl-23327920

Subject(s)

Gene Dosage/physiology; Genes, Tumor Suppressor/physiology; Histone Deacetylase 1/genetics; Histone Deacetylase 2/genetics; Proto-Oncogene Proteins c-myc/physiology; Tumor Suppressor Protein p53/physiology; Animals; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/pathology; Cells, Cultured; Epistasis, Genetic/physiology; Gene Dosage/genetics; Gene Expression Regulation/genetics; Gene Expression Regulation/physiology; Genes/physiology; Histone Deacetylase 1/metabolism; Histone Deacetylase 1/physiology; Histone Deacetylase 2/metabolism; Histone Deacetylase 2/physiology; Lymphoma/genetics; Lymphoma/pathology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proto-Oncogene Proteins c-myc/genetics; Proto-Oncogene Proteins c-myc/metabolism; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism

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Full text: 1 Database: MEDLINE Main subject: Genes, Tumor Suppressor / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-myc / Gene Dosage / Histone Deacetylase 1 / Histone Deacetylase 2 Limits: Animals Language: En Year: 2013 Type: Article

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