The anticancer drug tamoxifen counteracts the pathology in a mouse model of duchenne muscular dystrophy.

Dorchies, Olivier M; Reutenauer-Patte, Julie; Dahmane, Elyes; Ismail, Heham M; Petermann, Olivier; Patthey- Vuadens, Ophélie; Comyn, Sophie A; Gayi, Elinam; Piacenza, Tony; Handa, Robert J; Décosterd, Laurent A; Ruegg, Urs T

Dorchies, Olivier M; Reutenauer-Patte, Julie; Dahmane, Elyes; Ismail, Heham M; Petermann, Olivier; Patthey- Vuadens, Ophélie; Comyn, Sophie A; Gayi, Elinam; Piacenza, Tony; Handa, Robert J; Décosterd, Laurent A; Ruegg, Urs T.

Affiliation

Dorchies OM; Department of Pharmacology, University of Geneva and University of Lausanne, Geneva, Switzerland. olivier.dorchies@unige.ch

Am J Pathol ; 182(2): 485-504, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23332367

Subject(s)

Antineoplastic Agents/therapeutic use; Muscular Dystrophy, Animal/drug therapy; Muscular Dystrophy, Animal/pathology; Muscular Dystrophy, Duchenne/drug therapy; Muscular Dystrophy, Duchenne/pathology; Tamoxifen/therapeutic use; Animals; Antineoplastic Agents/pharmacology; Behavior, Animal/drug effects; Biomarkers/metabolism; Biomechanical Phenomena/drug effects; Body Weight/drug effects; Creatine Kinase/blood; Diaphragm/pathology; Diaphragm/physiopathology; Disease Models, Animal; Feeding Behavior/drug effects; Fibrosis; Mice; Muscle Contraction/drug effects; Muscle Fibers, Skeletal/drug effects; Muscle Fibers, Skeletal/pathology; Muscular Dystrophy, Animal/blood; Muscular Dystrophy, Animal/physiopathology; Muscular Dystrophy, Duchenne/blood; Muscular Dystrophy, Duchenne/physiopathology; Myocardium/pathology; Organ Size/drug effects; Receptors, Estrogen/metabolism; Tamoxifen/blood; Tamoxifen/pharmacology

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Database: MEDLINE Main subject: Tamoxifen / Muscular Dystrophy, Duchenne / Muscular Dystrophy, Animal / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals Language: En Year: 2013 Type: Article

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