Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.

Colabufo, Nicola A; Contino, Marialessandra; Cantore, Mariangela; Capparelli, Elena; Perrone, Maria Grazia; Cassano, Giuseppe; Gasparre, Giuseppe; Leopoldo, Marcello; Berardi, Francesco; Perrone, Roberto

Colabufo, Nicola A; Contino, Marialessandra; Cantore, Mariangela; Capparelli, Elena; Perrone, Maria Grazia; Cassano, Giuseppe; Gasparre, Giuseppe; Leopoldo, Marcello; Berardi, Francesco; Perrone, Roberto.

Affiliation

Colabufo NA; Dipartimento Farmacia, Università degli Studi di Bari ALDO MORO, Via Orabona 4, 70125 Bari, Italy. nicolaantonio.colabufo@uniba.it

Bioorg Med Chem ; 21(5): 1324-32, 2013 Mar 01.

Article in En | MEDLINE | ID: mdl-23347803

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; ATP-Binding Cassette Transporters/metabolism; Multidrug Resistance-Associated Proteins/metabolism; Naphthalenes/chemistry; ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; ATP-Binding Cassette Transporters/antagonists & inhibitors; Animals; Caco-2 Cells; Cell Proliferation/drug effects; Dogs; Drug Carriers/chemistry; Drug Carriers/metabolism; Humans; Madin Darby Canine Kidney Cells; Multidrug Resistance-Associated Proteins/antagonists & inhibitors; Naphthalenes/chemical synthesis; Naphthalenes/toxicity; Oxazoles/chemistry; Rhodamine 123/chemistry; Structure-Activity Relationship; Substrate Specificity; Thiazoles/chemistry

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Full text: 1 Database: MEDLINE Main subject: ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP-Binding Cassette Transporters / Multidrug Resistance-Associated Proteins / Naphthalenes Limits: Animals / Humans Language: En Year: 2013 Type: Article

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