Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design.

Mok, N Yi; Chadwick, James; Kellett, Katherine A B; Casas-Arce, Eva; Hooper, Nigel M; Johnson, A Peter; Fishwick, Colin W G

Mok, N Yi; Chadwick, James; Kellett, Katherine A B; Casas-Arce, Eva; Hooper, Nigel M; Johnson, A Peter; Fishwick, Colin W G.

Affiliation

Mok NY; School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.

J Med Chem ; 56(5): 1843-52, 2013 Mar 14.

Article in En | MEDLINE | ID: mdl-23374014

Subject(s)

Amyloid Precursor Protein Secretases/antagonists & inhibitors; Aspartic Acid Endopeptidases/antagonists & inhibitors; Benzeneacetamides/chemical synthesis; Phenylacetates/chemical synthesis; Protease Inhibitors/chemical synthesis; Alzheimer Disease/enzymology; Benzeneacetamides/pharmacology; Cell Survival/drug effects; Drug Design; Humans; Phenylacetates/pharmacology; Protease Inhibitors/pharmacology; Software; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Phenylacetates / Protease Inhibitors / Aspartic Acid Endopeptidases / Benzeneacetamides / Amyloid Precursor Protein Secretases Limits: Humans Language: En Year: 2013 Type: Article

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