EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE).

Munro, Kathryn M; Dixon, Kirsty J; Gresle, Melissa M; Jonas, Anna; Kemper, Dennis; Doherty, William; Fabri, Louis J; Owczarek, Catherine M; Pearse, Martin; Boyd, Andrew W; Kilpatrick, Trevor J; Butzkueven, Helmut; Turnley, Ann M

Munro, Kathryn M; Dixon, Kirsty J; Gresle, Melissa M; Jonas, Anna; Kemper, Dennis; Doherty, William; Fabri, Louis J; Owczarek, Catherine M; Pearse, Martin; Boyd, Andrew W; Kilpatrick, Trevor J; Butzkueven, Helmut; Turnley, Ann M.

Affiliation

Munro KM; Centre for Neuroscience Research, The University of Melbourne, Victoria, Australia.

PLoS One ; 8(2): e55948, 2013.

Article in En | MEDLINE | ID: mdl-23390555

Subject(s)

Astrocytes/immunology; Axons/immunology; Encephalomyelitis, Autoimmune, Experimental/immunology; Receptor, EphA4/genetics; Spinal Cord/immunology; Adoptive Transfer; Animals; Astrocytes/pathology; Axons/pathology; Cell Movement; Encephalomyelitis, Autoimmune, Experimental/genetics; Encephalomyelitis, Autoimmune, Experimental/pathology; Female; Gene Deletion; Immunoglobulin Fc Fragments/immunology; Immunoglobulin Fc Fragments/pharmacology; Macrophages/immunology; Macrophages/pathology; Male; Mice; Mice, Knockout; Myelin-Oligodendrocyte Glycoprotein/immunology; Myelin-Oligodendrocyte Glycoprotein/pharmacology; Peptide Fragments/immunology; Peptide Fragments/pharmacology; Receptor, EphA4/antagonists & inhibitors; Receptor, EphA4/immunology; Severity of Illness Index; Spinal Cord/drug effects; Spinal Cord/pathology; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; T-Lymphocytes/pathology; T-Lymphocytes/transplantation

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Full text: 1 Database: MEDLINE Main subject: Spinal Cord / Axons / Astrocytes / Receptor, EphA4 / Encephalomyelitis, Autoimmune, Experimental Limits: Animals Language: En Year: 2013 Type: Article

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