The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner.
FEBS Lett
; 587(6): 711-6, 2013 Mar 18.
Article
in En
| MEDLINE
| ID: mdl-23395800
ABSTRACT
Early B-cell factor 1 (Ebf1) is a transcription factor whose inactivation in all cells results in high bone mass because of an increase in bone formation. This observation suggests Ebf1 may be an inhibitor of osteoblast differentiation. To test this contention, we analyzed Ebf1 pattern of expression and function in osteoblasts ex vivo and in vivo through osteoblast-specific inactivation in the mouse. We show here that in vivo deletion of Ebf1 in osteoblast progenitors does not affect osteoblast differentiation or bone formation accrual post-natally. These observations indicate that the phenotype described in Ebf1(-/)(-) mice is not osteoblast-autonomous.
Full text:
1
Database:
MEDLINE
Main subject:
Osteoblasts
/
Osteogenesis
/
Bone and Bones
/
Trans-Activators
/
Gene Expression Regulation, Developmental
Limits:
Animals
Language:
En
Year:
2013
Type:
Article