Palladium-catalyzed decarboxylative allylation and benzylation of N-alloc and N-Cbz indoles.
Org Lett
; 15(5): 1140-3, 2013 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-23427905
ABSTRACT
A set of general methods for the palladium-catalyzed decarboxylative C3-allylation and C3-benzylation of indoles, starting from the corresponding N-alloc and N-Cbz indoles, respectively, is reported. This chemistry provides ready access to a wide range of functionalized indolenines in good to excellent yields. A tandem process, wherein the palladium catalyzed allylation chemistry is coupled with a Mizoroki-Heck reaction, offers a simple route to cinnamylated products.
Full text:
1
Database:
MEDLINE
Main subject:
Palladium
/
Indoles
Language:
En
Year:
2013
Type:
Article