Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3.

Chan, Ping K; Torres, Raul; Yandim, Cihangir; Law, Pui P; Khadayate, Sanjay; Mauri, Marta; Grosan, Crina; Chapman-Rothe, Nadine; Giunti, Paola; Pook, Mark; Festenstein, Richard

Chan, Ping K; Torres, Raul; Yandim, Cihangir; Law, Pui P; Khadayate, Sanjay; Mauri, Marta; Grosan, Crina; Chapman-Rothe, Nadine; Giunti, Paola; Pook, Mark; Festenstein, Richard.

Affiliation

Chan PK; Gene Control Mechanisms and Disease Group, MRC Clinical Sciences Centre, Imperial College School Medicine, Hammersmith Hospital Campus. Du Cane Road, London, UK.

Hum Mol Genet ; 22(13): 2662-75, 2013 Jul 01.

Article in En | MEDLINE | ID: mdl-23474817

Subject(s)

Friedreich Ataxia/genetics; Friedreich Ataxia/metabolism; Histone Deacetylase Inhibitors/pharmacology; Histone Deacetylases/metabolism; Niacinamide/pharmacology; Trinucleotide Repeat Expansion; Acetylation/drug effects; Animals; Cell Line, Transformed; Chromatin/genetics; Chromatin/metabolism; Deoxyribonuclease I/metabolism; Epistasis, Genetic/drug effects; Gene Expression Regulation/drug effects; Gene Order; Genetic Loci; Heterochromatin/genetics; Histones/metabolism; Iron-Binding Proteins/genetics; Methylation; Mice; Mice, Transgenic; Models, Biological; Frataxin

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Full text: 1 Database: MEDLINE Main subject: Friedreich Ataxia / Niacinamide / Trinucleotide Repeat Expansion / Histone Deacetylase Inhibitors / Histone Deacetylases Type of study: Prognostic_studies Limits: Animals Language: En Year: 2013 Type: Article

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