A child exposed to primidone not prescribed for her.
Ther Drug Monit
; 35(2): 145-9, 2013 Apr.
Article
in En
| MEDLINE
| ID: mdl-23503440
ABSTRACT
A 7.5-year-old girl who was treated with phenobarbital (PHB) for epilepsy was admitted with decreased levels of consciousness. She had been known to have high PHB levels of unknown cause, without symptoms. Her PHB levels were very high, as expected, but primidone levels were also detected although she and her parents denied history of primidone administration. We wished to rule out intentional unprescribed use of primidone. Our retrospective review showed 3 other children with high PHB concentrations where primidone was also detected when PHB levels were over 130 µmol/L. Complementary studies confirmed that high-dose PHB can convert to its prodrug primidone, which has not been reported previously.
Full text:
1
Database:
MEDLINE
Main subject:
Phenobarbital
/
Primidone
/
Anticonvulsants
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Animals
/
Child
/
Female
/
Humans
Language:
En
Year:
2013
Type:
Article