Mutational inactivation of herpes simplex virus 1 microRNAs identifies viral mRNA targets and reveals phenotypic effects in culture.

Flores, Omar; Nakayama, Sanae; Whisnant, Adam W; Javanbakht, Hassan; Cullen, Bryan R; Bloom, David C

Flores, Omar; Nakayama, Sanae; Whisnant, Adam W; Javanbakht, Hassan; Cullen, Bryan R; Bloom, David C.

Affiliation

Flores O; Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina, USA.

J Virol ; 87(12): 6589-603, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23536669

Subject(s)

Herpesvirus 1, Human/physiology; Immediate-Early Proteins/genetics; MicroRNAs/genetics; Mutation; RNA, Viral/genetics; Ubiquitin-Protein Ligases/genetics; Viral Proteins/genetics; Virus Replication/genetics; Animals; Binding Sites; Cell Line; Fibroblasts/virology; Gene Expression Regulation, Viral; HEK293 Cells; Herpesvirus 1, Human/genetics; Humans; Immediate-Early Proteins/metabolism; Mice; NIH 3T3 Cells; Neurons/virology; Phenotype; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Viral/metabolism; RNA-Induced Silencing Complex; Rabbits; Ubiquitin-Protein Ligases/metabolism; Viral Proteins/metabolism; Virus Replication/physiology

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Full text: 1 Database: MEDLINE Main subject: Viral Proteins / Virus Replication / RNA, Viral / Immediate-Early Proteins / Herpesvirus 1, Human / MicroRNAs / Ubiquitin-Protein Ligases / Mutation Limits: Animals / Humans Language: En Year: 2013 Type: Article

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