Correlations between pharmacokinetics of IgG antibodies in primates vs. FcRn-transgenic mice reveal a rodent model with predictive capabilities.

Tam, Susan H; McCarthy, Stephen G; Brosnan, Kerry; Goldberg, Kenneth M; Scallon, Bernard J

Tam, Susan H; McCarthy, Stephen G; Brosnan, Kerry; Goldberg, Kenneth M; Scallon, Bernard J.

Affiliation

Tam SH; Biologics Research; Janssen Research & Development, LLC; Spring House, PA USA.
McCarthy SG; Biologics Research; Janssen Research & Development, LLC; Spring House, PA USA.
Brosnan K; Biologics Toxicology; Janssen Research & Development, LLC; Spring House, PA USA.
Goldberg KM; Nonclinical Statistics & Computing; Janssen Research & Development, LLC; Spring House, PA USA.
Scallon BJ; Biologics Research; Janssen Research & Development, LLC; Spring House, PA USA.

MAbs ; 5(3): 397-405, 2013.

Article in En | MEDLINE | ID: mdl-23549129

Subject(s)

Histocompatibility Antigens Class I/genetics; Immunoglobulin Fc Fragments/administration & dosage; Immunoglobulin G/administration & dosage; Receptors, Fc/genetics; Respiratory Syncytial Viruses/immunology; Animals; Clinical Trials as Topic; Female; Half-Life; Haplorhini; Heterozygote; Homozygote; Humans; Immunoglobulins, Intravenous/administration & dosage; Metabolic Clearance Rate/genetics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Predictive Value of Tests; Serum Albumin/administration & dosage; Viral Fusion Proteins/immunology

Key words

FcRn; HSA; IVIG; PK; Tg276; Tg32; antibody; correlations; primates; transgenic mice

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Full text: 1 Database: MEDLINE Main subject: Respiratory Syncytial Viruses / Immunoglobulin G / Immunoglobulin Fc Fragments / Receptors, Fc / Histocompatibility Antigens Class I Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Year: 2013 Type: Article

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