Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos.

Fatokun, A A; Liu, J O; Dawson, V L; Dawson, T M

Fatokun, A A; Liu, J O; Dawson, V L; Dawson, T M.

Affiliation

Fatokun AA; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. amos.fatokun@nottingham.ac.uk

Br J Pharmacol ; 169(6): 1263-78, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23550801

Subject(s)

Cell Death/drug effects; Drug Discovery; Flavones/pharmacology; Flavonoids/pharmacology; Neurons/drug effects; Neuroprotective Agents/pharmacology; Poly(ADP-ribose) Polymerases/metabolism; Alkylating Agents/antagonists & inhibitors; Alkylating Agents/toxicity; Animals; Cell Line, Tumor; Cell Survival/drug effects; Cells, Cultured; Cerebral Cortex/cytology; Cerebral Cortex/drug effects; Cerebral Cortex/metabolism; Embryo, Mammalian/cytology; Enzyme Activation/drug effects; Flavones/chemistry; Flavonoids/chemistry; High-Throughput Screening Assays; Humans; Methylnitronitrosoguanidine/chemistry; Methylnitronitrosoguanidine/toxicity; Mice, Inbred Strains; Nerve Tissue Proteins/agonists; Nerve Tissue Proteins/antagonists & inhibitors; Nerve Tissue Proteins/metabolism; Neurons/cytology; Neurons/metabolism; Neuroprotective Agents/chemistry; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases/chemistry; Small Molecule Libraries; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Flavonoids / Cell Death / Poly(ADP-ribose) Polymerases / Neuroprotective Agents / Flavones / Drug Discovery / Neurons Type of study: Diagnostic_studies / Screening_studies Limits: Animals / Humans Language: En Year: 2013 Type: Article

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