Benzeneacetamides/pharmacology; Cell Differentiation; Enzyme Inhibitors/pharmacology; Glioma/enzymology; Glioma/pathology; Imidazoles/pharmacology; Isocitrate Dehydrogenase/antagonists & inhibitors; Isocitrate Dehydrogenase/genetics; Animals; Benzeneacetamides/administration & dosage; Benzeneacetamides/toxicity; Cell Differentiation/drug effects; Cell Transformation, Neoplastic; Enzyme Inhibitors/toxicity; Gene Expression Profiling; Gene Expression Regulation, Neoplastic/drug effects; Glioma/drug therapy; Glioma/genetics; Glutarates/metabolism; Histones/metabolism; Imidazoles/administration & dosage; Imidazoles/toxicity; Isocitrate Dehydrogenase/chemistry; Isocitrate Dehydrogenase/metabolism; Methylation; Mice; Mice, SCID; Mutant Proteins/antagonists & inhibitors; Mutant Proteins/chemistry; Mutant Proteins/metabolism; Protein Multimerization; RNA Interference; Xenograft Model Antitumor Assays