IL-1ß inhibits self-renewal capacity of dormant CD34âº/CD38â» acute myelogenous leukemia cells in vitro and in vivo.

Yang, Jing; Ikezoe, Takayuki; Nishioka, Chie; Nobumoto, Atsuya; Yokoyama, Akihito

IL-1ß inhibits self-renewal capacity of dormant CD34âº/CD38â» acute myelogenous leukemia cells in vitro and in vivo.

Yang, Jing; Ikezoe, Takayuki; Nishioka, Chie; Nobumoto, Atsuya; Yokoyama, Akihito.

Affiliation

Yang J; Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.

Int J Cancer ; 133(8): 1967-81, 2013 Oct 15.

Article in En | MEDLINE | ID: mdl-23564444

Subject(s)

ADP-ribosyl Cyclase 1/metabolism; Antigens, CD34/metabolism; Interleukin-1beta/metabolism; Interleukin-1beta/pharmacology; Leukemia, Myeloid, Acute/metabolism; STAT5 Transcription Factor/antagonists & inhibitors; Animals; Apoptosis/drug effects; Cell Cycle/drug effects; Cyclin-Dependent Kinase Inhibitor p21/biosynthesis; DNA Methylation; Down-Regulation; Humans; Janus Kinase 2/metabolism; Leukemia, Myeloid, Acute/drug therapy; Mice; Mice, Inbred NOD; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/metabolism; Promoter Regions, Genetic/genetics; STAT5 Transcription Factor/metabolism; Tumor Cells, Cultured

Key words

IL-1ß; STAT5; leukemia stem cells; quiescence

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Antigens, CD34 / ADP-ribosyl Cyclase 1 / STAT5 Transcription Factor / Interleukin-1beta Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2013 Type: Article

Fulltext

XML

PubMed Links

Search on Google