Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.

Jörg, Manuela; Shonberg, Jeremy; Mak, Frankie S; Miller, Neil D; Yuriev, Elizabeth; Scammells, Peter J; Capuano, Ben

Jörg, Manuela; Shonberg, Jeremy; Mak, Frankie S; Miller, Neil D; Yuriev, Elizabeth; Scammells, Peter J; Capuano, Ben.

Affiliation

Jörg M; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Bioorg Med Chem Lett ; 23(11): 3427-33, 2013 Jun 01.

Article in En | MEDLINE | ID: mdl-23602401

Subject(s)

Adenosine A2 Receptor Antagonists/chemical synthesis; Receptor, Adenosine A2A/chemistry; Adenosine A2 Receptor Antagonists/chemistry; Adenosine A2 Receptor Antagonists/metabolism; Binding Sites; Humans; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Receptor, Adenosine A2A/metabolism; Triazines/chemistry; Triazoles/chemistry

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Full text: 1 Database: MEDLINE Main subject: Receptor, Adenosine A2A / Adenosine A2 Receptor Antagonists Limits: Humans Language: En Year: 2013 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Receptor, Adenosine A2A / Adenosine A2 Receptor Antagonists Limits: Humans Language: En Year: 2013 Type: Article