Crystal structure of an anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain.

Fenn, Sebastian; Schiller, Christian B; Griese, Julia J; Duerr, Harald; Imhof-Jung, Sabine; Gassner, Christian; Moelleken, Joerg; Regula, Joerg Thomas; Schaefer, Wolfgang; Thomas, Markus; Klein, Christian; Hopfner, Karl-Peter; Kettenberger, Hubert

Fenn, Sebastian; Schiller, Christian B; Griese, Julia J; Duerr, Harald; Imhof-Jung, Sabine; Gassner, Christian; Moelleken, Joerg; Regula, Joerg Thomas; Schaefer, Wolfgang; Thomas, Markus; Klein, Christian; Hopfner, Karl-Peter; Kettenberger, Hubert.

Affiliation

Fenn S; Large Molecule Research, Pharma Research and Early Development, Roche Dignostics GmbH, Penzberg, Germany.

PLoS One ; 8(4): e61953, 2013.

Article in En | MEDLINE | ID: mdl-23613981

Subject(s)

Angiopoietin-2/immunology; Antibodies, Bispecific/chemistry; Antibodies, Bispecific/metabolism; Immunoglobulin Fab Fragments/chemistry; Immunoglobulin Fab Fragments/metabolism; Immunoglobulin Variable Region/chemistry; Immunoglobulin Variable Region/metabolism; Amino Acid Sequence; Crystallography, X-Ray; HEK293 Cells; Humans; Models, Molecular; Molecular Sequence Data; Protein Stability; Protein Structure, Tertiary; Static Electricity; Structure-Activity Relationship; Temperature

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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin Variable Region / Immunoglobulin Fab Fragments / Antibodies, Bispecific / Angiopoietin-2 Type of study: Prognostic_studies Limits: Humans Language: En Year: 2013 Type: Article

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