Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes.

Floreani, Maura; De Martin, Sara; Gabbia, Daniela; Barbierato, Massimo; Nassi, Alberto; Mescoli, Claudia; Orlando, Rocco; Bova, Sergio; Angeli, Paolo; Gola, Elisabetta; Sticca, Antonietta; Palatini, Pietro

Floreani, Maura; De Martin, Sara; Gabbia, Daniela; Barbierato, Massimo; Nassi, Alberto; Mescoli, Claudia; Orlando, Rocco; Bova, Sergio; Angeli, Paolo; Gola, Elisabetta; Sticca, Antonietta; Palatini, Pietro.

Affiliation

Floreani M; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

PLoS One ; 8(4): e61983, 2013.

Article in En | MEDLINE | ID: mdl-23626760

Subject(s)

Ascites/genetics; Cytochrome P-450 CYP1A1/metabolism; Cytochromes/metabolism; Enzyme Induction/genetics; Liver Cirrhosis, Experimental/genetics; Liver/enzymology; Receptors, Aryl Hydrocarbon/metabolism; Animals; Ascites/chemically induced; Ascites/enzymology; Ascites/pathology; Benzo(a)pyrene; Cytochrome P-450 CYP1A1/genetics; Cytochrome P-450 CYP1A2; Cytochromes/genetics; Gene Expression Regulation; Liver/pathology; Liver Cirrhosis, Experimental/chemically induced; Liver Cirrhosis, Experimental/enzymology; Liver Cirrhosis, Experimental/pathology; Liver Function Tests; Male; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Rats, Wistar; Receptors, Aryl Hydrocarbon/genetics; Severity of Illness Index; Transcription, Genetic

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Full text: 1 Database: MEDLINE Main subject: Ascites / Enzyme Induction / Receptors, Aryl Hydrocarbon / Cytochrome P-450 CYP1A1 / Cytochromes / Liver / Liver Cirrhosis, Experimental Limits: Animals Language: En Year: 2013 Type: Article

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