Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases.

Arrighi, Nicola; Bodei, Serena; Zani, Danilo; Michel, Martin C; Simeone, Claudio; Cosciani Cunico, Sergio; Spano, Pierfranco; Sigala, Sandra

Arrighi, Nicola; Bodei, Serena; Zani, Danilo; Michel, Martin C; Simeone, Claudio; Cosciani Cunico, Sergio; Spano, Pierfranco; Sigala, Sandra.

Affiliation

Arrighi N; Urology Unit, Istituto Clinico Città di Brescia, Brescia, Italy. dr.arrighi@live.it

Pharmacol Res ; 74: 1-6, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23628881

Subject(s)

Cell Proliferation; Myocytes, Smooth Muscle/metabolism; Receptors, Muscarinic/physiology; Urinary Bladder/cytology; Aged; Atropine/pharmacology; Benzofurans/pharmacology; Carbachol/pharmacology; Cells, Cultured; Cholinergic Agonists/pharmacology; Gene Expression; Humans; Male; Mitogen-Activated Protein Kinases/metabolism; Muscarinic Antagonists/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Piperidines/pharmacology; Pirenzepine/analogs & derivatives; Pirenzepine/pharmacology; Proto-Oncogene Proteins c-akt/metabolism; Pyrrolidines/pharmacology; RNA, Messenger/metabolism

Key words

Human detrusor smooth; Muscarinic receptors; Muscle cell; Proliferation

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Full text: 1 Database: MEDLINE Main subject: Urinary Bladder / Receptors, Muscarinic / Myocytes, Smooth Muscle / Cell Proliferation Limits: Aged / Humans / Male Language: En Year: 2013 Type: Article

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