Geminin restrains mesendodermal fate acquisition of embryonic stem cells and is associated with antagonism of Wnt signaling and enhanced polycomb-mediated repression.

Caronna, Elizabeth A; Patterson, Ethan S; Hummert, Pamela M; Kroll, Kristen L

Caronna, Elizabeth A; Patterson, Ethan S; Hummert, Pamela M; Kroll, Kristen L.

Affiliation

Caronna EA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA.

Stem Cells ; 31(8): 1477-87, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23630199

Subject(s)

Embryonic Stem Cells/physiology; Geminin/physiology; Mesoderm/physiology; Polycomb-Group Proteins/physiology; Animals; Cell Differentiation/physiology; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; Geminin/genetics; Geminin/metabolism; Gene Expression Regulation, Developmental; Mesoderm/cytology; Mesoderm/metabolism; Mice; Microarray Analysis; Polycomb-Group Proteins/genetics; Polycomb-Group Proteins/metabolism; Repressor Proteins/genetics; Repressor Proteins/metabolism; Wnt Signaling Pathway

Key words

Embryonic stem cell; Geminin; Mesendoderm; Polycomb complex; Wnt

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Full text: 1 Database: MEDLINE Main subject: Embryonic Stem Cells / Polycomb-Group Proteins / Geminin / Mesoderm Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Year: 2013 Type: Article

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