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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
Zak, Mark; Hurley, Christopher A; Ward, Stuart I; Bergeron, Philippe; Barrett, Kathy; Balazs, Mercedesz; Blair, Wade S; Bull, Richard; Chakravarty, Paroma; Chang, Christine; Crackett, Peter; Deshmukh, Gauri; DeVoss, Jason; Dragovich, Peter S; Eigenbrot, Charles; Ellwood, Charles; Gaines, Simon; Ghilardi, Nico; Gibbons, Paul; Gradl, Stefan; Gribling, Peter; Hamman, Chris; Harstad, Eric; Hewitt, Peter; Johnson, Adam; Johnson, Tony; Kenny, Jane R; Koehler, Michael F T; Bir Kohli, Pawan; Labadie, Sharada; Lee, Wyne P; Liao, Jiangpeng; Liimatta, Marya; Mendonca, Rohan; Narukulla, Raman; Pulk, Rebecca; Reeve, Austin; Savage, Scott; Shia, Steven; Steffek, Micah; Ubhayakar, Savita; van Abbema, Anne; Aliagas, Ignacio; Avitabile-Woo, Barbara; Xiao, Yisong; Yang, Jing; Kulagowski, Janusz J.
Affiliation
  • Zak M; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA. mzak@gene.com
J Med Chem ; 56(11): 4764-85, 2013 Jun 13.
Article in En | MEDLINE | ID: mdl-23659214
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Pyrroles / Antirheumatic Agents / Janus Kinase 1 / Janus Kinase 2 / Heterocyclic Compounds, 3-Ring / Imidazoles Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Language: En Year: 2013 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Pyrroles / Antirheumatic Agents / Janus Kinase 1 / Janus Kinase 2 / Heterocyclic Compounds, 3-Ring / Imidazoles Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Language: En Year: 2013 Type: Article