FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma.

Shu, Xing-Sheng; Li, Lili; Ji, Mingfang; Cheng, Yingduan; Ying, Jianming; Fan, Yichao; Zhong, Lan; Liu, Xiaodong; Tsao, Sai Wah; Chan, Anthony T C; Tao, Qian

Shu, Xing-Sheng; Li, Lili; Ji, Mingfang; Cheng, Yingduan; Ying, Jianming; Fan, Yichao; Zhong, Lan; Liu, Xiaodong; Tsao, Sai Wah; Chan, Anthony T C; Tao, Qian.

Affiliation

Shu XS; Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong and CUHK Shenzhen Research Institute, Shatin, Hong Kong.

Carcinogenesis ; 34(9): 1984-93, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23677067

Subject(s)

Genes, Tumor Suppressor; Nasopharyngeal Neoplasms/genetics; Nasopharynx/metabolism; Polycomb Repressive Complex 2/metabolism; Proto-Oncogene Proteins c-mdm2/metabolism; Transcription Factors/genetics; Carcinoma; Cell Line, Tumor; DNA Methylation/genetics; Enhancer of Zeste Homolog 2 Protein; Epithelial Cells; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms/metabolism; Nasopharyngeal Neoplasms/pathology; Nasopharynx/pathology; Polycomb Repressive Complex 2/genetics; Promoter Regions, Genetic; Proto-Oncogene Proteins c-mdm2/genetics

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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Nasopharynx / Nasopharyngeal Neoplasms / Genes, Tumor Suppressor / Proto-Oncogene Proteins c-mdm2 / Polycomb Repressive Complex 2 Type of study: Prognostic_studies Limits: Humans Language: En Year: 2013 Type: Article

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