Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat.

Lundblad, Cornelia; Axelberg, Helen; Grände, Per-Olof

Lundblad, Cornelia; Axelberg, Helen; Grände, Per-Olof.

Affiliation

Lundblad C; Department of Anesthesiology and Intensive Care, Lund University Hospital, Lund University, Lund, Sweden. cornelia.lundblad@med.lu.se

Acta Anaesthesiol Scand ; 57(6): 713-8, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23683126

Subject(s)

Lysophospholipids/agonists; Plasma Volume/drug effects; Propylene Glycols/therapeutic use; Sepsis/physiopathology; Sphingosine/analogs & derivatives; Animals; Capillary Leak Syndrome/drug therapy; Capillary Leak Syndrome/etiology; Capillary Permeability/drug effects; Cecum/injuries; Disease Models, Animal; Diuresis/drug effects; Drug Evaluation, Preclinical; Edema/etiology; Edema/prevention & control; Endothelium, Vascular/drug effects; Fingolimod Hydrochloride; Hematocrit; Hemodynamics/drug effects; Hemoglobins/analysis; Intestinal Perforation/complications; Male; Propylene Glycols/pharmacology; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis/blood; Sepsis/etiology; Sphingosine/agonists; Sphingosine/pharmacology; Sphingosine/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Plasma Volume / Propylene Glycols / Sphingosine / Lysophospholipids / Sepsis Type of study: Etiology_studies Limits: Animals Language: En Year: 2013 Type: Article

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