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AlCl3-mediated hydroarylation-heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest.
Nakhi, Ali; Archana, Sivakumar; Seerapu, Guru Pavan Kumar; Chennubhotla, Keerthana Sarma; Kumar, Kummari Lalith; Kulkarni, Pushkar; Haldar, Devyani; Pal, Manojit.
Affiliation
  • Nakhi A; Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India.
Chem Commun (Camb) ; 49(56): 6268-70, 2013 Jul 18.
Article in En | MEDLINE | ID: mdl-23732749
ABSTRACT
An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.
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Full text: 1 Database: MEDLINE Main subject: Quinoxalines / Chlorides / Aluminum Compounds / Sirtuins / Embryo, Nonmammalian / Alkenes / Enzyme Inhibitors / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2013 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Quinoxalines / Chlorides / Aluminum Compounds / Sirtuins / Embryo, Nonmammalian / Alkenes / Enzyme Inhibitors / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2013 Type: Article